异丁醇_MSDS化学品安全技术说明书

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异丁醇-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

异丁醇; Isobutyl alcohol; CAS:78-83-1

理化性质

为无色挥发性液体。分子式C4-H10-O。分子量74.12。沸点108.3℃。蒸气相对密度2.56。10％溶于水（20℃）。

接触机会

在用其作香料、溶剂、成型剂、清洁剂、调味品中接触本品。

国内主要生产厂商:吉林化肥厂、兰州化肥厂、上海人民化工厂、淄博石油化工厂、北京燕山石化总公司向阳化工厂

侵入途径

可经消化道、呼吸道以及皮肤吸收。

毒理学简介

大鼠经口LD50: 2460 mg/kg；吸入LCLo: 8000 ppm/4H。兔经皮LD50: 3400 mg/kg。

对眼和咽喉部有刺激作用,大量时可有麻醉作用。IDLH: +1600 ppm [R24]

临床表现

接触较高浓度后可出现眼、鼻、咽喉刺激症状。污染皮肤后,局部出现轻度充血和红斑。

*SLIGHT ERYTHEMA WITHOUT THE FORMATION OF WHEALS WAS OBSERVED ... FOLLOWING THE APPLICATION OF ISOBUTYL ALCOHOL TO THE SKIN OF MAN. IRRITATION OF THE EYES AND THROAT, FORMATION OF VACUOLES IN THE SUPERFICIAL LAYERS OF THE CORNEA, AND LOSS OF APPETITE & WT WERE REPORTED AMONG WORKERS SUBJECTED TO AN UNDETERMINED, BUT APPARENTLY HIGH, CONCN OF ISOBUTYL ALCOHOL & BUTYL ACETATE. [R8, 4581]

*A CASE IS REPORTED OF OCCUPATIONALLY ACQUIRED SENSITIVITY TO ISOPROPYL ALCOHOL IN WHICH, ON TESTING WITH GAS CHROMATOGRAPHICALLY PURIFIED MATERIAL, POSITIVE PATCH TEST REACTIONS WERE FOUND TO 1-PROPANOL, 1-BUTANOL, 2-PROPANOL, 2-BUTANOL. [R40]

*REPORT OF 3 CASES WITH SEVERE VERTIGO AFTER HANDLING BUTANOL & ISOBUTANOL. [R41]

*ACUTE TOXICITY IS ABOUT 3 TIMES THAT OF ETHYL ALCOHOL. IT IS MORE IRRITATING THAN ETHYL BUT LESS SO THAN AMYL. [R39,p. II-175]

*BEHAVIORAL FUNCTIONAL TESTS ON WORKERS WHO WERE OCCUPATIONALLY EXPOSED TO A MIXTURE OF SOLVENTS INDICATED A SIGNIFICANT IMPAIRMENT OF PERFORMANCES. [R42]

*INDUSTRIAL EXPOSURE TO MIXED VAPORS OF BUTYL ACETATE & ISOBUTYL ALCOHOL HAS CAUSED VACUOLAR KERATITIS IN SEVERAL WORKERS, BUT IT IS NOT KNOWN WHICH OF THE SUBSTANCES WAS RESPONSIBLE. [R43]

*IN HIGH CONCN ... /IS A CNS DEPRESSANT/. [R1]

*... ISOBUTYL ALCOHOL /WAS STUDIED/ UNDER SAME CONDITIONS OF EXPOSURE AS FOR N-BUTYL ALCOHOL. NO EVIDENCE OF EYE IRRITATION WAS NOTED WITH REPEATED 8 HR EXPOSURES TO LEVELS ON THE ORDER OF 100 PPM. [R8, 4581]

*... BUTYL ALCOHOLS HAVE PRODUCED FEW CASES OF POISONING IN INDUSTRY BECAUSE OF THEIR LOW VOLATILITY. /BUTYL ALCOHOLS/ [R27, 564]

*ETHANOL & CERTAIN SHORT CHAIN ARYL (BENZYL) & ALIPHATIC (PROPYL, BUTYL) ALCOHOLS PRODUCED UP TO 10 FOLD INCR IN CYCLIC AMP CONCN IN PURIFIED HUMAN PERIPHERAL BLOOD LYMPHOCYTES. ETHANOL CONCN AS LOW AS 80 MG/DL PRODUCED SIGNIFICANT ELEVATIONS IN LYMPHOCYTE CYCLIC AMP. [R44]

处理

对症处理。

标准

车间空气卫生标准:

美国ACGIH TLV-TWA 152 mg/m3 (50 ppm)

美国MSHA STANDARD-air: TWA 100 ppm (300 mg/m3)

美国OSHA PEL(所有行业): 8H TWA 100 ppm (300 mg/m3)

澳大利亚: TWA 50 ppm (150 mg/m3) JAN 1993;

奥地利: TWA 100 ppm (300 mg/m3) JAN 1993;

比利时: TWA 50 ppm (152 mg/m3) JAN 1993;

丹麦: STEL 50 ppm (150 mg/m3), Skin JAN 1993;

法国: TWA 50 ppm (150 mg/m3) JAN 1993;