标识

中文名：十溴代联苯醚; 十溴代二苯醚;

英文名：Decabromobiphenyl ether; Decabromodiphenyl ether; DeBDE;

CAS: 1163-19-5

分子式: C12-Br10-O

理化性质

本品是一种无嗅纯白色的粉末。溴的含量为81～83% 。温度>320,>400,和425℃时分解。挥发性1%(319℃)。熔点290～306℃。在标温和常压下稳定。蒸气压<10^6mmHg(20℃)、<1mmHg(250℃)、2.03mmHg(278℃)、5.03mmHg(306℃)。蒸气密度3.0/3.25(20℃)。分子量959.22。

接触机会

本品是一种高效阻燃剂,用于热塑树脂、热固性树脂、纺织、胶粘剂和涂料。在高强度聚苯乙烯、尼龙、环氧树脂、合成橡胶等领域也广泛使用。

侵入途径

经消化道、呼吸道及皮肤吸收均少。

毒理学简介

大鼠经口LD  :>2 gm/kg；经皮LD  :>3 gm/kg。

急性毒性低。另有报道大鼠吸入LC50>48.2mg/L。商品的兔急性经皮LD50>2g/kg。

用商品一次给雌性大鼠灌胃126～200mg/kg,在14天内,未引起任何毒性或大体的病变。5只雄性大鼠一次灌胃5g/kg,在14天观察期中无死亡,动物体重增长正常。

雄、雌大鼠各10只暴露于商品浓度为2或48.2mg/L空气中1小时,观察14天,全部动物存活。2mg/L组中第1天2只大鼠有流涎;以后在观察期内,除1只动物呼吸困难,另1只第4天有流泪外,其余动物均正常。48.1mg/L组动物出现眼斜视、活动增加,3～7天中有4只动物先后出现呼吸困难,7～12天中有些动物出现眼斜视及流泪,第14天所有动物均正常。

大鼠及小鼠喂纯度>97%的本品,饮食中的水平为100g/kg(4w)或50g/kg(13W),不引起有害影响。

兔涂皮应用200或2000mg/kg,观察14天,无死亡发生。本品对兔皮肤和兔眼为非刺激剂。

大鼠经口染毒,经胃肠道吸收少,并于食后迅速排出。本品在体内的半衰期<24小时,主要随粪排出,尿及呼气中<1% 。

本品对人的皮肤为非致敏剂。

临床表现

未见人中毒的报道。

美国HSDB引用文献：

*Thyroid and reproductive dysfunction was investigated in workers exposed for at least 240 hr to decabromobiphenyl and decabromobiphenyloxide over a 4 yr period. The average period of employment was 3.9 yr. Air samples of decabromobiphenyl in the manufacturing area showed 0.18 to 0.23 mg/cu m for an 8 hr time weighted average. Of 18 workers exposed for 3 yr or longer, thyroid nodules were seen in 3; another nodule was seen in a worker exposed to high chlorine concentrations. Significant correlation was seen between length of employment and concentrations of follicle stimulating hormone in workers exposed to decabromobiphenyl. An abnormal follicle stimulating hormone value was found in only one worker. A testicular cyst was found in one exposed worker, and epididymal nodules in two others. No testicular or epididymal nodules were seen among comparisons. No detectable decarbromobiphenyl was found in serum. It was concluded that thyroid hyperplasia may result from exposure to decarbromobiphenyl, but no definite statement can be made concerning adverse effects on the prevalence of testicular and epididymal nodules because of their prevalence in the general population. [R9]

处理

立即脱离事故现场。皮肤或眼污染时立即用清水冲洗。

对症处理

标准

车间空气卫生标准：俄罗斯: STEL 3 mg/m3 JAN 1993

参考文献

WHO. EHC162:Brominated diphenyl ethers. Geneva: WHO, 1994:57～130 　　　　

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