仲丁醇_MSDS化学品安全技术说明书

仲丁醇-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

仲丁醇; 2-丁醇; 2-羟基丁烷; 甲基乙基甲醇; Sec-Butylalcohol; 2-Butanol; 2-Hydroxybutane; Methylethylcarbinol; CAS：78-92-2

理化性质

无色挥发性液体,有醇味。分子式C4-H10-O。分子量74.12。相对密度0.808(20/4℃)。凝固点-89℃。沸点99.5℃。闪点-23.89℃。自燃点406.11℃。蒸气密度2.55。蒸气压1.33kPa(10mmHg 20℃)。蒸气与空气混合物爆炸限1.7～9.8% 。溶于12份水; 与乙醇、乙醚。遇热、明火、氧化剂易燃。

接触机会

作为溶剂,用于油漆、树胶、天然树脂。并可作为染料、水果香精。

国内主要生产厂商:北京化工厂

侵入途径

呼吸道、消化道。

毒理学简介

大鼠经口LD50: 6480 mg/kg; 吸入LCLo: 16000 ppm/4H。

微毒。高浓度可致麻醉。对兔眼有严重损伤。

IDLH: +2000 ppm [R19]

临床表现

大量吸入时有眼、鼻、咽喉刺激症状,及头痛、晕眩、倦怠、恶心等症状。

美国HSDB引用文献：

*... BUTYL ALCOHOLS HAVE PRODUCED FEW CASES OF POISONING IN INDUSTRY BECAUSE OF THEIR LOW VOLATILITY. /BUTYL ALCOHOLS/ [R12]

*Symptomatology: 1. Central nervous system: headache, muscle weakness, giddiness, ataxia, confusion, delirium, coma. 2. Gastrointestinal: nausea, vomiting, diarrhea (odor of the alcohol in excreta). 3. Irritation of skin, eyes, throat from vapor or liquid. Cough and dyspnea. 4. Death from resp failure. 5. Disturbances of cardiac rhythm. 6. Occasional complications: a. Gastrointestinal hemorrhage b. Renal damage with glycosuria c. Liver damage d. Cardiac failure e. Pulmonary edema ... /Alcohols (higher)/ [R31,p. III-14]

*TWO PT WITH ALCOHOL DERMATITIS & HYPERSENSITIVITY TO PRIMARY ALCOHOLS WERE TESTED FOR HYPERSENSITIVITY TO SECONDARY ALCOHOLS. GAS CHROMATOGRAPHICALLY PURE 2-BUTANOL PRODUCED AN INTENSE ECZEMATOUS RESPONSE IN BOTH. [R32]

*Short term exposure: Overexposure to sec-butyl alcohol may cause ... headache, dizziness, and drowsiness. Long term exposure: Drying and cracking of the skin may result from prolonged skin exposure. [R16, 1]

*AS EXTRAPOLATED FROM RAT DATA ... 3 TO 7 OZ REPRESENTS REASONABLE EST OF SINGLE ORAL MEAN LETHAL DOSE OF ANY BUTYL ALCOHOL IN MAN. /ALCOHOLS, HIGHER/ [R31,p. III-13]

*A CASE IS REPORTED OF OCCUPATIONALLY ACQUIRED SENSITIVITY TO ISOPROPYL ALCOHOL IN WHICH, ON TESTING WITH GAS CHROMATOGRAPHICALLY PURIFIED MATERIAL, POSITIVE PATCH TEST REACTIONS WERE FOUND TO 1-PROPANOL, 1-BUTANOL, 2-PROPANOL, 2-BUTANOL. [R33]

*ETHANOL & CERTAIN SHORT CHAIN ARYL (BENZYL) & ALIPHATIC (PROPYL, BUTYL) ALCOHOLS PRODUCED UP TO 10 FOLD INCR IN CYCLIC AMP CONCN IN PURIFIED HUMAN PERIPHERAL BLOOD LYMPHOCYTES. ETHANOL CONCN AS LOW AS 80 MG/DL PRODUCED SIGNIFICANT ELEVATIONS IN LYMPHOCYTE CYCLIC AMP. [R34]

处理

对症处理。

标准

车间空气卫生标准：

美国ACGIH TLV-TWA (100 ppm)

美国MSHA STANDARD-air: TWA 150 ppm (450 mg/m3)

美国OSHA PEL(所有行业): 8H TWA 150 ppm (450 mg/m3)

澳大利亚: TWA 100 ppm (305 mg/m3), STEL 150 ppm (455 mg/m3)

奥地利: TWA 100 ppm (300 mg/m3)

比利时: TWA 100 ppm (303 mg/m3), STEL 150 ppm (455 mg/m3)

丹麦: STEL 50 ppm (150 mg/m3), 皮肤

芬兰: TWA 50 ppm (150 mg/m3), STEL 75 ppm (225 mg/m3), 皮肤