品名

亚硒酸钠; Sodium selenite; CAS：10102-18-8

理化性质

白色针状结晶（五结晶水盐）或柱状结晶（无水盐）。在干燥空气中被脱水。在40℃时可变成无水盐。分子式Na2-Se-O3。分子量172.95。易溶于水（68g/100ml,20℃）,不溶于乙醇。

接触机会

主要用于玻璃脱色剂,生物碱试剂。

国内主要生产厂商:北京化工厂、广西化工研究所、陕西省石化厅精细化工公司实验厂、山东淄博饲料添加剂原料药厂、广州化学试剂厂、广州汕头市金砂区精细化工厂

侵入途径

呼吸道、消化道。

毒理学简介

大鼠经口LD50: 7 mg/kg。小鼠经口LD50: 7080 ug/kg。

高毒，毒性较硒酸钠强。估计人口服1g能引起中毒死亡。参见 硒酸纳。

临床表现

参见 硒酸纳。

美国HSDB引用文献：

*... A 57 yr old female ... took daily doses of tablets that accidentally contained about 31 mg selenium (probably the major amount in the form of selenite). After approx 11 days she noted marked hair loss which eventually developed into alopecia. ... Two wk later, she noted white horizontal streaking on her fingernails, tenderness and swelling of the finger tips, and purulent discharge. Over a 3 wk period all fingernails were affected, and one fingernail was lost. She had periodic episodes of nausea and vomiting, a sour milk breath odor and felt increased fatigue. ... She had consumed 77 tablets. Four days after the last tablet her serum selenium level was 0.528 ug/ml. /Selenite/ [R26, 500]

*/In 1983 Chinese report/ ... a 62 yr old man with moderate dietary intake of selenium who took about 0.9 mg selenium as sodium selenite per day to maintain his health. After 2 yr, his blood and hair levels were 0.179 ug/ml and 0.828 ug/mg, respectively, and it was noticed that he had thickened fragile nails. It was concluded that a daily intake of about 1 mg selenium as selenite can be toxic, and that selenite selenium produces toxic reactions more readily than cereal selenium /(SRP: brewers yeast)/. [R26, 502]

处理

对症处理。静注10％硫代硫酸钠10～20ml，可使部分硒化合物还原成元素硒而减低毒性。BAL可增加硒的毒性,大量的维生素Ｃ可减少硒的排泄,均不宜使用。皮肤污染用清水冲洗。

美国HSDB引用文献：

*EXPTL THERAPY: PROTECTIVE EFFECTS OF THIOSULFATE, SULFATE, OR AMINO ACIDS AGAINST SELENOSIS IN RATS ARE NOT PREDICTIVE OF PROTECTIVE OR THERAPEUTIC EFFECTS AGAINST ACUTE SELENOSIS IN SWINE. IN PARENTERAL ADMIN, THEY ARE CONTRAINDICATED FOR TREATMENT OF SELENOSIS IN SWINE. [R23]

标准

车间空气卫生标准

美国ACGIH TLV-TWA 0.2 mg(Se)/m3

美国MSHA STANDARD-air: TWA 0.2 mg(Se)/m3

美国OSHA PEL(所有行业): 8H TWA 0.2 mg(Se)/m3

ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN93.

澳大利亚:TWA 0.2 mg(Se)/m3 JAN93.

比利时:TWA 0.2 mg(Se)/m3 JAN93.

丹麦:TWA 0.1 mg(Se)/m3 JAN93.

芬兰:TWA 0.1 mg(Se)/m3; STEL 0.3 mg(Se)/m3 JAN93.

德国:TWA 0.1 mg(Se)/m3 JAN93.

匈牙利:STEL 0.1 mg(Se)/m3 JAN93.

荷兰:TWA 0.2 mg(Se)/m3 JAN93.

菲律宾:TWA 0.2 mg(Se)/m3 JAN93.

波兰:TWA 0.1 mg(Se)/m3 JAN93.

瑞典:TWA 0.1 mg(Se)/m3 JAN93.

瑞士:TWA 0.1 mg(Se)/m3 JAN93.

土耳其:TWA 0.2 mg(Se)/m3 JAN93.

英国:TWA 0.1 mg(Se)/m3 JAN93.

保加利亚，哥伦比亚，约旦，韩国 参照美国 ACGIH TLV.

新西兰，新加坡，越南 参照美国 ACGIH TLV

危规：GB6.1 类61016。原铁规:无机剧毒品,81016。

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