亚硒酸_MSDS化学品安全技术说明书

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亚硒酸-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

亚硒酸; Selenious acid; CAS：7783-00-8

理化性质

无色透明六方柱状结晶。在空气中渐潮解,储于干燥器中则能风化,容易被氧化还原。分子式H2-Se-O3。分子量128.98。相对密度3.004(15℃/4℃)。易溶于水(90g/100ml,0℃、乙醇,不溶于氨水。

接触机会

用作生物碱试剂、农药, 因此在生产和使用工人及实验室人员可接触。

国同内主要生产厂商:北京化工厂、天津市化学试剂一厂、天津市化学试剂三厂、广州化学试剂厂、成都化学试剂厂

侵入途径

呼吸道。

毒理学简介

大鼠经口LDLo：25mg/kg。大鼠腹腔注射LDLo：10mg/kg。

临床表现

刺激皮肤，可引起皮肤灼伤和皮炎; 可经皮肤吸收中毒。国外有误服含亚硒酸化学品中毒死亡的报告。

美国HSDB引用文献：

*One death due to selenium has been reported. A 3 yr old boy swallowed an unknown amount of a liquid containing 1.8% selenious acid and other poisons. He rapidly became comatose with unrecordable blood pressure and peripheral pulse, and died after 1.5 hr. There was garlic odor of the breath. [R17, 499]

*A case of fatal suicidal ingestion of Super Blue (Gun Blue) (gun-blueing) is presented. Postmortem examination of the patient revealed pulmonary edema with pleural effusion and congestion of the kidney. Necrosis of proximal tubules was found in the kidney by histological examination. Super Blue contains 4% selenious acid and 2.5% cupric sulfate in hydrochloric acid. Levels of selenium and copper in tissues of the toxic case and normal individuals were determined. The selenium levels of tissues of the patient were 9-90 fold higher than that of normal subjects, whereas concentrations of copper were about 2 fold compared to that of control levels. The highest levels of selenium in the tissues of the patient were found in the lung, kidney and stomach contents. [R19]

*A 2 yr old male child ingested approximately 15 ml of a Gun Blue solution containing selenious acid, nitric acid and copper nitrate. He was immediately given milk and vomited spontaneously blood stained food with a garlic smell. He was admitted ... less than 3 hr following ingestion. An esophago-gastroscopy showed a second degree burn of both esophagus and stomach. He became comatose and had to be ventilated mechanically. Metabolic acidosis, leucocytosis, hyperglycemia and hemoconcentration were also observed. During the following day he developed a severe intestinal distension, a cardiomyopathy (DPK = 1,302, cardiac arrhythmia), and moderate hepatic, renal and pulmonary dysfunctions. Plasma selenium concentration was 285 ug/l and the maximum urinary concentration was 28,459 ug/l. After 4 days, his condition had improved considerably and he was about to be extubated when he suddenly developed acute respiratory distress. A similar episode occurred 24 hr later. His lung function progressively deteriorated; later he required the use of an extracorporeal membrane lung. Legionella dumofii was found the causative agent. He died 17 days after ingestion despite aggressive treatment. [R20]

*After ingestion of an unknown amount of a gun blueing compound containing selenious acid (11 ml from the bottle fluid were missing, equivalent to 2.9 g selenium a 2 year old girl suffered from continuous hypersalivation, vomiting, diarrhea, restlessness and muscle spasm. Blood pressure and pulse rate were increased. Symptomatic treatment was performed by parenteral fluid administration. The plasma selenium concentration was increased to 20 times normal 5 hr after ingestion. Erythrocyte selenium exceeded plasma selenium, 24 hr after intoxication. Urinary selenium excretion decreased parallel to the plasma selenium concentration. Ten weeks later, the selenium content of hair had risen to 10 times normal. The plasma glutathione peroxidase activity showed only a slight increase during the first 36 hr, erythrocyte glutathione peroxidase, catalase and superoxide dismutase activities were not significantly altered. The child fully recovered. [R21]

处理

参见<硒>。

标准

车间空气卫生标准:

美国ACGIH TLV-TWA 0.2 mg(Se)/m3

美国MSHA STANDARD-air: TWA 0.2 mg(Se)/m3

美国OSHA PEL(所有行业): 8H TWA 0.2 mg(Se)/m3

ARAB Republic of Egypt: TWA 0.2 mg(Se)/m3 JAN93;

澳大利亚: TWA 0.2 mg(Se)/m3 JAN93;

比利时: TWA 0.2 mg(Se)/m3 JAN93;

丹麦: TWA 0.1 mg(Se)/m3 JAN93;

芬兰: TWA 0.1 mg(Se)/m3, STEL 0.3 mg(Se)/m3 JAN93;