二硫化四甲基秋兰姆_MSDS化学品安全技术说明书

二硫化四甲基秋兰姆-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

二硫化四甲基秋兰姆; 四甲基二硫代双甲硫羰酰胺; 四甲基秋兰姆; 秋兰姆; 福美双; 阿锐生; 促进剂TMTD; 促进剂T; Tetramethylthiuram disulfide; Bis(dimethylthiocarbamoyl) disulfide; Thiuram; Thiram; Thiosun; Arasan; CAS：137-26-8

理化性质

白色或淡黄色晶体。分子式C6-H12-N2-S4。分子量240.44。相对密度1.29。熔点155～156℃(商业品146℃)。溶于苯、丙酮、氯仿和二硫化碳; 微溶于乙醇和乙醚; 不溶于水。可燃。燃烧生成硫氧化物; 而末燃着物质有能生成二硫化碳。

接触机会

用作丁苯、丁腈、顺丁、丁基等合成橡胶的超速促进剂,农用杀菌剂和杀虫剂等。

国内主要生产厂商:江苏省南通化工三厂、上海市长江化工厂

侵入途径

主要为皮肤接触。可经消化道吸收。

毒理学简介

人吸入TCLo: 30 ug/m3/5Y-I。

大鼠经口LD50: 560 mg/kg; 吸入LC50: 500 mg/m3/4H。小鼠经口LD50: 1250 mg/kg。兔经皮LDLo: 1 gm/kg。

低毒类。人的LD估计为0.8g/kg。

实验动物急性中毒时,呈明显嗜睡、上升性麻痹及肝、肾和脑等脏器损害。对皮肤、粘膜具刺激性。

IDLH: *100 mg/cu m [R22]

临床表现

皮肤接触后可致变应性与刺激性接触性皮炎（见变应性与刺激接触性皮炎的临床表现和诊断）。以1％浓度作皮肤斑贴试验常获阳性反应。

接触本品前后饮酒可致面部血管扩张、充血、血压下降,心率和呼吸增快,剧烈恶心、呕吐。

美国HSDB专家小组平审：

*IT HAS BEEN NOTED THAT CUTANEOUS EXPOSURE TO THIRAM WILL PRODUCE ... INHIBITION OF ALDEHYDE DEHYDROGENASE ... . [R36]

*SYMPTOMATOLOGY: (The primary toxic reaction, not that induced by alcohol, as inferred in part from clinical reports of disulfiram /the ethyl analogue of thiram/ overdoses): 1. Nausea, vomiting, diarrhea, anorexia, weight loss. Nausea and emesis may be persistent and the diarrhea copious. 2. Headache, lethargy, dizziness, ataxia, confusion, drowsiness, emotional lability and coma. 3. Delirium, tremor, catatonia and hallucinations have occurred with large repeated doses of disulfiram, apparently in the absence of ethanol intake. 4. Reduction in blood pressure, not usually severe unless fluid and electrolyte deficits are extensive. 5. Suppression of tendon reflexes. 6. Hypotonia and, within a few hours or a few days, flaccid paralysis ... 7. Respiratory paralysis and death. 8. Severe dermatitis and hepatitis probably represent hypersensitivity reactions. 9. Peripheral neuropathies in patients on chronic disulfiram therapy tend to disappear spontaneously over periods of a few months after the therapy is discontinued. /Disulfiram/ [R5,p. III-384]

处理

参见<化学物致变应性接触性皮炎的治疗>及<化学物致刺激性接触性皮炎的治疗>。对症治疗。接触者严禁饮酒。

美国HSDB专家小组平审：

*If a large amount of thiram has been swallowed and effective vomiting has not already occurred, the stomach should be emptied by intubation, aspiration, and lavage, taking all precautions to protect the airway from aspiration of vomitus. Lavage should be followed by instillation of activated charcoal and cathartic. Syrup of Ipecac administration is not advisable because the contained alcohol (2%) may possibly induce an "Antabuse" reaction. [R33]

*If only a small amount of thiram has been ingested and/or treatment has been delayed, oral administration of activated charcoal and cathartic probably represents optimal management. [R33]

*In severe poisonings, intravenous infusion of glucose solution protects the liver and supports mechanisms of detoxication and excretion. If vomiting and diarrhea are severe, fluid balance and serum electrolytes should be monitored, and appropriate electrolyte solutions infused to correct losses. [R34]

标准

车间空气卫生标准：

美国ACGIH TLV-TWA 1 mg/m3

美国MSHA STANDARD-air: TWA 5 mg/m3

美国OSHA PEL(所有行业): 8H TWA 5 mg/m3

澳大利亚: TWA 5 mg/m3

奥地利: TWA 5 mg/m3

比利时: TWA 5 mg/m3

丹麦: TWA 2 mg/m3

芬兰: TWA 5 mg/m3, STEL 10 mg/m3, 皮肤

法国: TWA 5 mg/m3

德国: TWA 5 mg/m3