品名

二异丙胺; Diisopropylamine; CAS：108-18-9

理化性质

无色有氨味的液体。分子式 C6-H15-N。分子量101.19。相对密度0.722(22℃)。沸点84℃。闪点-1℃。自燃点315.56℃。蒸气密度3.5。蒸气与空气混合物可燃限 1.1～7.1 % 。微溶于水; 溶于大多数有机溶剂。水溶液呈强碱性。遇热、明火易燃。能与氧化剂发生剧烈反应。受热分解放出有毒氮氧化物。

接触机会

有机合成和用作催化剂时接触本品。

国内主要生产厂商: 上海联合化工厂、兰州西固区农药厂、上海红卫农药厂、上海东海化工厂

侵入途径

经消化道和呼吸道吸收。

毒理学简介

大鼠经口LD50: 770 mg/kg; 吸入LC50: 4800 mg/m3/2H。小鼠经口LD50: 2120 mg/kg; 吸入 LC50: 4200 mg/m3/2H（1014ppm）。兔经皮LD50: >10 gm/kg。属低毒。

IDLH: +200 ppm

临床表现

在生产条件下,吸入200～500mg/m^3,经2～3小时,可出现视物模糊、头痛及恶心。

美国HSDB引用文献：

*Employees should be screened for history of certain medical conditions which might place the employee at increased risk from diisopropylamine exposure. /These are/ ... chronic respiratory disease ... skin disease ... /and/ eye disease. ... Any employee developing the above-listed conditions should be referred for further medical examination. [R15]

*DIISOPROPYLAMINE IS AN EYE IRRITANT... WORKERS EXPOSED TO CONCN BETWEEN 25 AND 50 PPM... IN 2 INSTANCES, THERE WERE...COMPLAINTS OF NAUSEA AND HEADACHE. PROLONGED SKIN CONTACT IS LIKELY TO CAUSE DERMATITIS. [R21, 3155]

*Symptoms: Nausea in low concentrations and pulmonary edema in high concentrations. [R9]

*Inhalation of vapors causes irritation, sometimes with nausea and vomiting;  can also cause burns to the respiratory system. ... /Liquid/ causes smarting of the skin and first-degree burns on short exposure;  may cause second-degree burns on long exposure. [R12]

*In humans, diisopropylamine is an eye irritant. When exposed to concentrations between 25 and 50 ppm, workers complained of disturbances of vision. There were also complaints of nausea and headache. [R22]

*Edema of the epithelium of the cornea, generally without pain, has been produced by amine vapors, causing colored haloes to be seen around lights, usually in the evening, after industrial exposure to the vapors of various amines including ... diisopropylamine. [R23]

*TEMPORARY IMPAIRMENT OF VISION HAS OCCURRED IN MEN AFTER EXPOSURE TO VAPOR CONCN...AS LOW AS 25 TO 50 PPM IN AIR DURING DISTILLATION OF DIISOPROPYLAMINES /PRESUMABLY DUE TO INJURY TO CORNEAL EPITHELIUM/... [R24]

处理

溅入眼内或沾染皮肤时,应用水彻底冲洗。可用2％普鲁卡因滴眼,涂用眼膏等治疗。皮肤冲洗后可用2% 硼酸液湿敷。

吸入中毒者,可对症处理。无特效解毒剂。

标准

车间空气卫生标准:

美国ACGIH TLV-TWA 21 mg/m3 (5 ppm) (皮肤)

美国MSHA STANDARD-air: TWA 5 ppm (20 mg/m3) (皮肤)

美国OSHA PEL(所有行业): 8H TWA 5 ppm (20 mg/m3) (皮肤)

澳大利亚: TWA 5 ppm (20 mg/m3), 皮肤

比利时: TWA 5 ppm (21 mg/m3), 皮肤

丹麦: TWA 5 ppm (20 mg/m3), 皮肤

芬兰: STEL 5 ppm (20 mg/m3), 皮肤

法国: TWA 5 ppm (20 mg/m3), 皮肤

荷兰: TWA 5 ppm (20 mg/m3), 皮肤

菲律宾: TWA 5 ppm (20 mg/m3), 皮肤

俄罗斯: STEL 5 mg/m3, 皮肤

瑞士: TWA 5 ppm (20 mg/m3), 皮肤

英国: TWA 5 ppm (20 mg/m3), 皮肤

保加利亚,哥伦比亚,约旦,韩国 参照美国 ACGIH TLV;

新西兰,新加坡,越南 参照美国 ACGIH TLV

危规: GB 3.2 类 32170。原铁规: 一级易燃液体, 61144。UN NO.1158。IMDG CODE 3073页, 3.2 类。 　　　　

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