乙二醇单甲基醚_MSDS化学品安全技术说明书

乙二醇单甲基醚-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

乙二醇单甲基醚; 2-甲氧基乙醇; 甲基溶纤剂; Ethylene glycol monomethyl ether; 2-Methoxyethanol; Methylcellosolve; CAS：109-86-4

理化性质

无色液体,略有气味。分子式C3-H8-O2。分子量76.10。相对密度0.966(20/4℃)。凝固点-86.5 ℃。沸点124.5℃。闪点46.11℃(开杯)。自燃点285℃。蒸气密度2.62。蒸气压0.83kPa(6.2 mmHg20℃)。蒸气与空气混合物爆炸限2.5～14% 。与水、乙醇、乙醚、甘油、丙酮、二甲基甲酰胺混溶。遇热、明火可燃。能与氧化物反应生成爆炸性过氧化物。

接触机会

用作溶剂及其他使用和生产过程中可能接触。

国内主要生产厂商:抚顺石油二厂、上海试剂三厂、天津化学试剂一厂

侵入途径

消化道、呼吸道与皮肤。

毒理学简介

人经口LDLo: 3380 mg/kg; 吸入TCLo: 25 ppm。

大鼠经口LD50: 2370 mg/kg; 吸入LC50: 1500 ppm/7H。小鼠经口LD50: 2560 mg/kg; 吸入LC50: 1480 ppm/7H。兔经皮LD50: 1280 mg/kg。

属低毒类。大剂量可引起实验动物严重的肾脏损害。兔皮肤反复和长时间接触本品,未出现明显刺激,但中毒剂量可通过皮肤吸收。本品作用于兔眼时,可立即产生结膜刺激和轻微暂时性角膜翳,24小时内可消退。

临床表现

国外曾有因饮入200ml混有本品的甜酒而引起死亡的病例报告。尸检发现出血性胃肠炎、肾小管退行性变和脂肪变性。又曾报道因吸入本品蒸气而引起两则中毒病例。症状为无力、失眠、头痛、胃肠功能障碍、夜尿、体重减轻、眼烧灼感、反应迟钝、嗜睡。临床检查发现巨幼红细胞性贫血。

美国HSDB引用文献：

*CHRONIC POISONINGS FROM VAPORS OF ... METHYL CELLOSOLVE ... HAVE OCCURRED IN THIS COUNTRY. TOXIC ENCEPHALOPATHY & EVIDENCE OF BONE MARROW DEPRESSION WITHOUT HEMOLYSIS WERE KEY FINDINGS ... LUNG, KIDNEY & LIVER CHANGES HAVE ALSO BEEN OBSERVED ... [R9,p. III-175]

*MAY CAUSE ANEMIA, MACROCYTOSIS, APPEARANCE OF YOUNG GRANULOCYTES IN BLOOD ... [R1]

*... A DEATH /WAS REPORTED/ AFTER INGESTION OF METHYL CELLOSOLVE, WITH POST-MORTEM FINDINGS OF HEMORRHAGIC GASTRITIS ... REPORTED TWO CASES OF ENCEPHALOPATHY IN WORKERS USING 2-METHOXYETHANOL AS A CLEANER. CONFUSION, DISORIENTATION, LETHARGY, AND ANOREXIA WERE PRESENT IN BOTH CASES. TREMORS, AGITATION, WEIGHT LOSS, BLURRED VISION, FEVER, HEADACHE, AND BED WETTING ... MARKED ANEMIA AND BONE MARROW DAMAGE ... WERE FOUND IN BOTH PATIENTS, AND ONE HAD PANCYTOPENIA. THE MORE SEVERELY AFFECTED WORKER HAD BEEN EXPOSED A FEW MONTHS, THE OTHER FOR ONLY ONE MONTH. [R29]

*TO DETERMINE WHETHER EMPLOYEES POTENTIALLY EXPOSED TO ETHYLENE GLYCOL MONOMETHYL ETHER DURING MFG AND PACKAGING HAD A HIGHER PREVALENCE OF ANEMIA, LEUKOPENIA OR STERILITY THAN AN IN-PLANT COMPARISON GROUP, A CROSS-SECTIONAL STUDY WAS CONDUCTED AT THE MICHIGAN DIV OF DOW CHEM USA. BLOOD SAMPLES ON 65 OF 97 POTENTIALLY EXPOSED AND CONTROL WHITE MALES, AND SEMEN SAMPLES FROM A SUBSET OF 15 WERE ANALYZED. WITH THE POSSIBLE EXCEPTION OF SMALLER TESTICULAR SIZE, NO GROSS ABNORMALITIES OR CLINICALLY MEANINGFUL DIFFERENCES IN HEMATOLOGICAL OR FERTILITY INDICES WERE NOTED. RESULTS OF REGRESSION MODELING SUGGESTED THAT WHITE BLOOD CELLS AND HEMOGLOBIN HAVE BEEN DECR AT HIGHER EXPOSURE LEVELS. [R31]

*The first reported case of a possible toxic effecct of ethylene glycol monomethyl ether (EGME) exposure in the microfilm manufacturing industry was described. Reversible subjective CNS complaints and asymptomatic hematopoietic effects occurred following inhalation and skin exposure to EGME. [R33]

*Overexposure to methyl cellosolve may cause irritation of the eyes, nose, and throat, drowsiness, weakness, and shaking. Swallowing methyl cellosolve may be fatal. ... Prolonged or repeated exposure may cause headache ... fatigue, staggering, personality change, and decr mental ability. Anemia and other blood changes may result. [R17]

IDLH: +200 ppm [R19]

处理

对症治疗。

标准

车间空气卫生标准：

美国ACGIH TLV-TWA 16 mg/m3 (5 ppm) (皮肤)

美国MSHA STANDARD-air: TWA 25 ppm (80 mg/m3) (皮肤)

美国OSHA PEL(所有行业): 8H TWA 25 ppm (80 mg/m3) (皮肤)

澳大利亚: TWA 5 ppm (16 mg/m3), 皮肤

比利时: TWA 5 ppm (16 mg/m3), 皮肤

丹麦: TWA 5 ppm (16 mg/m3), 皮肤

芬兰: TWA 25 ppm (80 mg/m3), STEL 40 ppm (120 mg/m3), 皮肤