品名

乙二醇单丁基醚; 2-丁氧基乙醇; 丁基溶纤剂; Ethylene glycol monobutyl ether; 2-Butoxyethanol; N-Butoxyethanol; Butyl cellosolve; CAS：111-76-2

理化性质

无色液体; 略有醚味。分子式C6-H14-O2。分子量118.20。相对密度0.9012(20/20℃)。凝固点-74.8℃。沸点168.4～170.2℃。闪点71.11℃(开杯)。自燃点244.44℃。蒸气压40.0kPa(300mmHg 140℃)。蒸气与空气混合物燃烧限1.1～10.6% 。25℃水中溶解度为5%; 溶于许多有机溶剂、矿物油。遇热、明火、强氧化剂可燃。

接触机会

作为多种树脂、喷漆、颜料、白蛋白、润滑油的溶剂和干燥清洁剂。也作为稀释剂和某些化学中间产物而广泛使用。

国内主要生产厂商:上海试剂三厂

侵入途径

消化道、呼吸道与皮肤。

毒理学简介

人（女性）经口TDLo: 600 mg/kg，7813 uL/kg。人吸入TCLo: 195 ppm/8H，100 ppm。

大鼠经口LD50: 470 mg/kg; 吸入LC50: 450 ppm/4H。小鼠经口LD50: 1230 mg/kg; 吸入LC50: 700 ppm/7H。兔经皮LD50: 220 mg/kg。

属中等毒。毒物的麻醉作用是引起动物死亡的主要原因。尸检见肺充血、严重肾脏充血和血红蛋白尿。小鼠吸入的死因为肺和肾脏损害。滴入动物眼内,对眼结膜、角膜有轻度暂时性损伤。兔皮肤长时反复接触本品仅引起轻微单纯的刺激。中毒剂量可通过皮肤迅速吸收。

IDLH: *700 ppm [R20]

临床表现

使用本品时仅引起粘膜刺激和头痛。未见急性职业中毒报道。

美国HSDB引用文献：

*EXPOSURE ... TO HIGH CONCN ... OF ... VAPORS, PROBABLY IN RANGE OF 300-600 PPM FOR SEVERAL HR WOULD BE EXPECTED TO CAUSE RESP & EYE IRRITATION ... /CNS DEPRESSION/, & DAMAGE TO KIDNEY & LIVER. [R30, 3933]

*FIRST SIGN OF ORGANIC ABNORMALITY ... RESULTING FROM EXCESSIVE EXPOSURE BY ANY ROUTE LIKELY WOULD BE ABNORMAL BLOOD PICTURE CHARACTERIZED BY ERYTHROPENIA, RETICULOCYTOSIS, GRANULOCYTOSIS, & LEUCOCYTOSIS. SOMEWHAT MORE INTENSE EXPOSURE WOULD BE LIKELY TO CAUSE FRAGILITY OF ERYTHROCYTES & HEMATURIA. [R30, 3933]

*BONE MARROW DAMAGE. /FROM TABLE/ [R31]

*2-Butoxyethanol penetrates the skin readily, and toxic action from excessive skin exposure may be more likely than from vapor inhalation. [R32, 163]

*IT APPEARS THAT THIS CHEMICAL IS ONE OF THE FEW MATERIALS TO WHICH HUMAN IS MORE RESISTANT THAN THE USUAL EXPERIMENTAL ANIMALS. THIS APPEARS TO BE DUE, IN PART AT LEAST, TO THE FACT THAT HUMANS ARE MORE RESISTANT THAN ARE MOST LAB ANIMALS TO THE HEMOLYTIC EFFECTS CAUSED BY THE MATERIAL ITSELF OR ITS METABOLITE. [R30, 3937]

*... REGARDED AS MOST TOXIC GLYCOL MONOALKYL ETHER USED AS SOLVENT ... . [R1, 610]

*THE EFFECTS /OF ALKYL DERIV OF ETHYLENE GLYCOL/ ... UPON THE CNS INCLUDE HEADACHE, DROWSINESS, WEAKNESS, SLURRED SPEECH, RECRUDESCENT STUTTERING, STAGGERING GAIT, TREMOR, AND BLURRED VISION. CHANGES OF PERSONALITY ARE OFTEN NOTED ... THESE CHANGES ARE SUCH THAT THE PATIENT, IN THE ABSENCE OF AN ACCURATE OCCUPATIONAL HISTORY, MAY BE TREATED FOR SCHIZOPHRENIA OR NARCOLEPSY. IN ACUTE POISONING WITH THE ETHYLENE GLYCOL MONOALKYL ETHERS, THERE IS ... RENAL INJURY: ALBUMINURIA & HEMATURIA. /ETHYLENE GLYCOL MONOALKYL ETHERS/ [R33]

*A case of severe poisoning with ethylene glycol butyl ether after massive ingestion is described. Deep coma, metabolic acidosis, hypokalemia hemoglobinuria, oxaluria and a transitory rise in the serum creatinine level were observed. The elimination of the various metabolites butoxyacetic acid and oxalate was assessed in urine and a metabolic pattern for ethylene glycol butyl ether is suggested. [R34]

*The effects of 2-butoxyethanol and its metabolites, 2-butoxyacetaldehyde and butoxyacetic acid, on erythrocytes from humans were investigated in vitro. ... Incubation of human blood with butoxyacetic acid showed minimal swelling or hemolysis of erythrocytes with minimal decline in blood ATP levels at butoxyacetic acid concentrations several-fold higher than required to cause complete hemolysis of rat erythrocytes. ... Human erythrocytes are comparatively insensitive to the hemolytic effects of butoxyacetic acid in vitro. [R35]

*A case of acute poisoning with ethylene glycol butyl ether is reported in a chronic alcoholic abuser. On admission the 53 yr old patient was comatose with metabolic acidosis, shock and noncardiogenic pulmonary edema confirmed by hemodynamic study. Following supportive treatment and hemodialysis the outcome was favorable. ... [R36]

*In several, single, 8 hour exposures of humans at concentrations of 200 or 100 ppm, no objective effects were seen except for urinary excretion of butoxyacetic acid. No increased osmotic fragility was observed in these short term exposures. Subjectively, these concentrations were found to be uncomfortable, and mild eye, nose, and throat irritation followed exposure. [R32, 163]

*No clinical signs of adverse effects nor subjective complaints occurred among seven male volunteers exposed at 20 ppm for 2 hours during light physical exercise. [R32, 163]

处理

对症治疗。

标准

危规：GB6.1 类61592。UN NO.2369。IMDG CODE 6085-1页,6.1 类。

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