三乙胺_MSDS化学品安全技术说明书

三乙胺-MSDS化学品安全技术说明书

发表时间：2011-10-31浏览次数：评论：分享：顶：踩：

品名

三乙胺; N,N-二乙基乙胺; Triethylamine; N,N-Diethylethanamine; CAS：121-44-8

理化性质

易挥发的无色液体。有氨味。分子式C6-H15-N。分子量101.19。相对密度0.7255(25/4℃)。熔点-114.8℃。沸点89.5℃。闪点-6.67℃(开杯)。蒸气密度3.48。蒸气压6.00kPa (45mmHg 20℃)。蒸气与空气混合物爆炸限1.2～8.0% 。稍溶于水（>18.7℃）,能与水混溶（<18.7℃）,与乙醇、乙醚混溶。水溶液呈碱性。遇热、明火、氧化剂易燃。能与氧化物反应。加热分解,生成氮氧化物。

接触机会

用于制橡胶硫化促进剂、润湿剂和杀菌剂等,也用作溶剂、有机合成、阻聚剂、染料。

国内主要生产厂商:北京化工厂、四川西南制药二厂、南京制药厂、上海东海化工厂

侵入途径

经皮肤、呼吸道和消化道吸收。

毒理学简介

人吸入TCLo: 12 mg/m3/11W-C。

大鼠经口LD50: 460 mg/kg; 吸入LCLo: 1000 ppm/4H。小鼠经口LD50: 546 mg/kg; 吸入LC50: 6 gm/m3。兔经皮LD50: 570 uL/kg。

人暴露于50ppm浓度可引起严重肺刺激症状; 一次吸入0.00026mg/L,脑电图上可反映出中枢神经系统变化。

实验动物出现眼和上呼道刺激症状、呼吸困难、共济失调、阵发性强直性痉挛。尸检见轻度肺水肿、心肌蛋白变性、肝肾脂肪变性。暴露0.18mg/L时影响条件反射。以800mg/kg剂量小鼠灌胃,几分钟后肠内二氨基氧化酶(组胺酶)活性明显抑制。血液内注入少量三乙胺可见血压降低(组胺效应)。将小鼠鼠尾浸入本品,2只小鼠分别于15分钟和30分钟后死亡。

本品对皮肤和眼具刺激作用。

IDLH: +200 ppm [R20, 318]

临床表现

接触本品可引起皮肤和粘膜刺激症状,亦可发生皮肤灼伤和眼灼伤。

美国HSDB引用文献：

*There have been reports of temporary blue hazy vision from subtle disturbance of the corneal epithelium in people exposed to ethylamines. ... Diethylamine has been identified as having this effect, but it is not clear whether ethylamine and triethylamine also have have this action. [R31, 413]

*A cross-sectional study of visual disturbances was conducted in 19 workers (13 men, 6 women, mean age 45) employed in a polyurethane foam production plant. Visual disturbances (foggy vision, blue haze, and sometimes halo phemomena) were reported by 5 workers. Symptoms were associated with work operations with the highest exposure to triethylamine (TWA= 12-13 mg/cu m). The level of dimethylethanolamine was below the detection limit. Detailed eye examinations of the 5 affected workers were normal. TWA levels of 10-15 mg/cu m for 4 to 8 hr may be associated with blue haze, while exposure for 2 hr at this level did not cause visual disturbances ... the TWA levels were well below the threshold limit value of 40 mg/cu m employed in 瑞典 and the USA. [R32]

*Two cases of keratitis in polyurethane workers are reported. Both subjects presented complaints of smoky, foggy, blurred vision. Slit lamp examination of one patient revealed subepithelial corneal vesicles approximately 30-50 um in diameter. Slit lamp examination of the other showed deep or subepithelial vacuolization only in the palpebral aperture. [R33]

处理

对症处理。

标准

车间空气卫生标准：

美国ACGIH TLV-STEL 12 mg/m3 (3 ppm) (皮肤)

美国ACGIH TLV-TWA 4.1 mg/m3 (1 ppm)

美国MSHA STANDARD-air: TWA 25 ppm (100 mg/m3)

美国OSHA PEL(所有行业): 8H TWA 25 ppm (100 mg/m3)

澳大利亚: TWA 10 ppm (40 mg/m3), STEL 15 ppm (60 mg/m3)

比利时: TWA 10 ppm (41 mg/m3), STEL 15 ppm (62 mg/m3)

丹麦: TWA 10 ppm (40 mg/m3)

芬兰: TWA 10 mg/m3, STEL 20 mg/m3, 皮肤