品名

邻苯二甲酸二-2-乙基己酯; Di(2-ethylhexyl)phthalate;  Bis(2-ethylhexyl) phthalate; CAS：117-81-7

理化性质

淡色液体。分子式C24-H38-O4。分子量390.62。相对密度0.986。熔点-30℃。沸点358℃。闪点218℃(闭杯)。自燃点410℃。不溶于水。遇热、明火可燃。能与氧化剂反应。加热分解,放出辛辣烟。

接触机会

化工中间体。

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侵入途径

毒性低,主要经胃肠吸收。

毒理学简介

人（男性）经口TDLo: 143 mg/kg。

大鼠经口LD50: 30 gm/kg; 经皮LDLo: 4 gm/kg。小鼠经口LD50: 1500 mg/kg; 经皮LDLo: 4 gm/kg。兔经皮LD50: 25 gm/kg。

受试大鼠出现液样便。

临床表现

以原液给人作皮肤斑贴试验,无刺激或过敏反应。

美国HSDB引用文献：

*/Dialysis patients were examined for liver changes/ ... These patients were receiving approx 150 mg of DEHP per wk intravenously during their treatment. At 1 month, no morphological liver changes were observed by liver biopsy. At 1 yr, peroxisomes were described as being "significantly higher in number". No other observations were made. ... livers in dialysis patients compared with those of healthy individuals would be exposed to a greater number of blood contaminants at higher levels because of their impaired clearance abilities. There were no other data describing the effects of DEHP in humans other than those proposed as possible effects in persons receiving intravenous solutions. [R27]

*... HUMAN DERMAL PATCH TESTING SHOWED NO IRRITATION OR SENSITIZATION. [R28, 2349]

*IN TWO HUMAN VOLUNTEERS WHO INGESTED 5 & 10 G ... NO SYMPTOMS OCCURRED FROM 5-G DOSE & ONLY MILD GASTRIC DISTURBANCES & LOOSE STOOLS FROM LARGER DOSE. [R28, 2349]

*OCCUPATIONAL EXPOSURE TO ATMOSPHERIC LEVELS OF 0.0006-0.01 PPM (0.001-0.016 MG/CU M) ... FOR 10-34 YR DID NOT INCREASE FREQUENCY OF CHROMOSOMAL ABERRATIONS IN BLOOD LEUKOCYTES. [R29]

*DEHP showed no increases in chromosomal aberrations in human fetal lung cells or human leukocytes. ... [R30]

+Healthy subjects were exposed to the inhalation of 0.5 or 2.0 mg/cu m of bis (2-ethylhexyl) phthalate 8 hours a day for five (5) days, group A and B, respectively. In group A, concn in blood incr after first exposure to 165 mug/l and after 2-5th exposure stabilized at 72-114 ug/l;  concn in urine after first exposure incr to 88.5 ug/l, moderated after second and third exposure, and after fifth exposure incr to 45.2 ug/l. In group B, after first exposure concn in blood and urine incr to 505 and 250 ug/l, respectively, and continuously incr during the following exposures to 803 and 576 ug/l, respectively, on day 5. Apparently, in both groups di(2-ethylhexyl) phthalate is accumulated faster that it can be metabolized or excreted. [R33]

*... A central nervous depressant if absorbed. /Phthalate acid esters/ [R37]

*... The phthalates represent one of the lowest toxicity classes used in industry. /Phthalates/ [R28, 2343]

处理

对症处理。

卫生标准

车间空气卫生标准：

美国ACGIH TLV-STEL 10 mg/m3

美国ACGIH TLV-TWA 5 mg/m3

美国MSHA STANDARD-air: TWA 5 mg/m3

美国OSHA PEL(所有行业): 8H TWA 5 mg/m3

澳大利亚: TWA 10 mg/m3

澳大利亚: TWA 5 mg/m3, STEL 10 mg/m3

比利时: TWA 5 mg/m3, STEL 10 mg/m3

丹麦: TWA 5 mg/m3, 致癌物

芬兰: TWA 5 mg/m3, STEL 10 mg/m3, 皮肤

法国: TWA 5 mg/m3

德国: TWA 10 mg/m3

匈牙利: TWA 5 mg/m3, STEL 10 mg/m3, 皮肤

荷兰: TWA 5 mg/m3

菲律宾: TWA 5 mg/m3

俄罗斯: STEL 1 mg/m3

瑞典: TWA 3 mg/m3, STEL 5 mg/m3

瑞士: TWA 5 mg/m3

英国: TWA 5 mg/m3, STEL 10 mg/m3

保加利亚,哥伦比亚,约旦,韩国 参照美国 ACGIH TLV;

新西兰,新加坡,越南 参照没，美国 ACGIH TLV

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