品名

苯甲酸苄酯; 苯基甲酸苄酯;  Benzylbenzoate;  Benzylphenylformate;  Benzylphenylcarboxylate;  Benoic acid benzyl ester; CAS：120-51-4

理化性质

无色油状液体,低室温时凝固为叶片状结晶。稍有香味。分子式C14-H12-O2。分子量212.24。相对密度1.114。熔点21℃。沸点323～324℃。闪点147.78℃(闭杯)。自燃点481.11℃。蒸气密度7.31。蒸气压2.0kPa(15mmHg)。不溶于水或甘油; 与乙醇、氯仿、乙醚、油混溶。能随水蒸气少量挥发。遇热、明火可燃。燃烧可释放一氧化碳。能与氧化剂反应。

接触机会

化工中间体,也用为镇痉药、杀螨剂、溶剂、定香剂(香料)、化妆品、纺织品染料。

国内主要生产厂商:上海试剂三厂、上海香料厂、杭州香料厂路桥分厂

侵入途径

主要经呼吸道吸入。

毒理学简介

大鼠经口LD50: 1700 uL/kg; 经皮LD50: 4 mL/kg。小鼠经口LD50: 1400 uL/kg。兔经皮LD50: 4 gm/kg。

毒性低,有降低血压的报道。

临床表现

未见职业中毒的报告。

美国HSDB引用文献：

*Benzyl benzoate is relatively nontoxic but may irritate the skin and eyes. Increased pruritus and irritation (manifested by burning and stinging, particularly of the genitalia and scalp) are common and may be severe in hot humid climates. [R14]

*LIQ IS IRRITATING TO EYES ON DIRECT CONTACT, BUT NO DAMAGE HAS BEEN REPORTED... [R18]

*A 2-month-old boy weighing 4.2 kg, who was hospitalized for scabies, was bathed over the body, except for the face, with a solution containing benzyl benzoate (43%), soap (20%), ethyl alcohol (20%), and distilled water (17%). Convulsions appeared 2.5 hr later and were controlled with diazepam. About 1.5 hr later, convulsions recurred requiring even stronger doses of diazepam. There was no hyperthermia, hypocalcemia, or hypoglycemia. The cerebrospinal fluid was normal, as were X-rays of the head. All organic causes and subdural hematoma were eliminated. It was highly probable that the condition was iatrogenic and that the etiological agent was the benzyl benzoate. However, this could not be proved, since benzyl benzoate was not found in the urine and since the quantity of urine was too small for analysis of metabolites such as hippuric acid. The boy apparently fully recovered and was in good health when last examined at 6 months of age. [R19, 1507]

*... A 7 year old boy died following a transplant for aplastic bone marrow. The etiology of his condition was not established with certainty. However, the month preceding diagnosis he was bathed over the body every other day with Ascabiol, a scabicide which contained benzyl benzoate (10%) and disulfiram (2%) in addition to ethyl alcohol, water, and polysorbate. It seemed likely that the condition resulted from chronic overdosage with the scabicide. [R19, 1507]

处理

对症处理。

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