品名

2,4,6-三氯酚; 2,4,6-Trichlorophenol; CAS：88-06-2

理化性质

无色针状晶体,有冲鼻酚味。分子式C6-H3-Cl3-O。分子量197.44。相对密度1.490(75/4℃)。熔点68℃。沸点℃。蒸气压0.13kPa(1mmHg 76.5℃)。微溶于水; 溶于热的酸; 易溶于乙醇及乙醚。溶液呈酸性。加热分解,生成氯化物。

接触机会

用作除草剂、脱叶剂、杀菌剂、防腐剂。

国内主要生产厂商:上海试剂一厂

侵入途径

经消化道吸收。

毒理学简介

大鼠经口LD50: 820 mg/kg。哺乳动物经皮LD50: 700 mg/kg。

动物出现不安和呼吸加快,后出现无力、震颤、阵挛性抽搐、气急、昏迷,甚至死亡。震颤不强烈,但持续较久。

临床表现

未见急性中毒报道。中毒症状可参见 <苯酚>。

美国HSDB引用文献：

+TRICHLOROPHENOLS ... PRODUCE REDNESS & EDEMA ON SKIN CONTACT & ON PROLONGED EXPOSURE EVEN MILD TO MODERATE CHEMICAL BURNS OF SKIN OF MAN. IN EYE THEY INDUCE CONJUNCTIVAL IRRITATION & SOMETIMES CORNEAL INJURY & IRITIS. DUSTS ARE IRRITATING TO NOSE & PHARYNX. SYSTEMIC EFFECTS ... PRESUMABLY RESEMBLE ... PHENOL ... . /TRICHLOROPHENOLS/ [R12]

+Symptoms and pulmonary function were evaluated in 7 subjects exposed to trichlorophenol. Symptoms from upper airways and chest were more common among exposed than in control subjects (60% and 10%). Significantly reduced forced expiratory flow at 75% of vital capacity and incr closing vol were measured, while other spirometric variables and the transfer factor of the lung for carbon monoxide were normal. Incr elastic recoil pressure of the lung and x-ray signs of lung tissue involvement were noticed in 2 subjects. The findings suggest an irritating effect on the lung of trichlorophenol, and it cannot be excluded that long-term exposure may produce pulmonary fibrosis. /Trichlorophenol/ [R38]

+Adverse health effects have been seen in workers exposed to chlorophenols contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin or to products synthesized from trichlorophenol. These effects, probably due to 2,3,7,8-tetrachlorodibenzo-p-dioxin, include persistent chloracne, liver dysfunction, neuromuscular weakness, porphyria and psychological changes. /Trichlorophenols/ [R40]

处理

对症处理。

标准

危规：GB6.1 类61705。原铁规:有机有毒品,84152。

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