品名

环丙烷; 三亚甲基; Cyclopropane;  Trimethylene;  CAS：75-19-4

理化性质

无色易燃有石油醚样气味的气体。分子式C3-H6。分子量42.08。密度1.879g/l(0℃)。熔点-126.6℃。沸点-33℃。自燃点500℃。蒸气密度1.48。蒸气与空气混合物爆炸限2.4～10.4% 。微溶于水; 溶于固定油; 易溶于乙醇、乙醚。性质不稳定,易变为开链化合物,较易被浓硫酸吸收。遇热、明火易燃烧爆炸。能与氧化剂反应。

接触机会

用于有机合成。医药上曾用作麻醉剂。

侵入途径

主要经呼吸道吸入。

毒理学简介

小鼠吸入LCLo: 282 gm/m3/2H。

对中枢神经系统具有麻醉作用。动物麻醉时血压和呼吸无明显影响。血液生化改变不大。在体内无蓄积性。

临床表现

吸入一定量环丙烷气体后有头昏、头痛感觉。

美国HSDB引用文献：

*CYCLOPROPANE INCR IRRITABILITY OF PACEMAKER & CONDUCTION TISSUES & VENTRICULAR ARRHYTHMIAS CAN OCCUR, ESPECIALLY IF ANESTHESIA IS DEEP OR VENTILATION IS INADEQUATE & HYPERCAPNIA DEVELOPS. [R13, 311]

*CYCLOPROPANE IS MINIMALLY IRRITATING TO THE RESPIRATORY TRACT, AND THEREFORE, RESPIRATORY ALTERATIONS SUCH AS BREATH-HOLDING, TACHYPNEA AND COUGHING ARE LESS FREQUENT... LARYNGO-SPASM MAY DEVELOP DURING INDUCTION... DELIRIUM DURING INDUCTION IS NOT UNCOMMON. [R11, 85]

*A VARIETY OF ARRHYTHMIAS MAY OCCUR DURING THE ADMINISTRATION OF CYCLOPROPANE, INCLUDING SINUS BRADYCARDIA, ATRIAL EXTRASYSTOLES, ATRIAL FIBRILLATION, A-V NODAL RHYTHMS, VENTRICULAR EXTRASYSTOLES, AND BIGEMINAL RHYTHM. [R11, 86]

*THERE IS NO EVIDENCE THAT CYCLOPROPANE IS HEPATOTOXIC... [R11, 86]

+A 22-yr-old white male was found dead in a storage room as a result of a fatal suicidal ingestion of cyclopropane. Autopsy findings revealed congestion and hemorrhagic edema of the lungs, congestion of the trachea, and early autolysis. Cyclopropane was determined by headspace gas chromatography and mass spectrometry. [R14]

处理

吸入环丙烷气体后如有头痛、头昏症状时,立即离开现场到新鲜空气处,可很快恢复。必要时可对症治疗。

标准

 车间空气卫生标准：荷兰TWA 690 mg/m^3（400 ppm）。

危规：GB2.1类21014。原铁规:易燃气体,32007。UN NO.1027。IMDG CODE 2070页,2类。副危险3类。(液化的) 　　　　

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