发表时间:2011-10-31浏览次数: 评论: 分享: 顶: 踩:
品名
氟磺酸甲酯; Magic Methyl; Methyl Fluorosulfate; CAS:421-20-5
理化性质
分子式:C-H3-F-O3-S。分子量:114.10。
毒理学简介
大鼠吸入LC50: 5 ppm/1H; 小鼠经口LD50: 112 mg/kg; 兔经皮 LDLo: 455 mg/kg。
剧毒!原发性刺激物。
临床表现
急性吸入引起角膜损伤和肺水肿。国外报导一名25岁的患者因衣服溅到少量的氟磺酸甲酯的液体而吸入致死的事故案例。(*INHALATION OF A MINUTE QUANTITY PROVED FATAL TO A 25-YR-OLD WHO SPILLED A FEW MILLILITERS OF FLUID CONTAINING ETHYLFLUOROSULFONATE ON HIS CLOTHING. [R5])。
处理
美国HSDB专家组建议:吸入本品后立即给激素治疗,并严密观察24小时(*IMMEDIATE ADMIN OF CORTICOSTEROIDS SHOULD BE CONSIDERED IF THIS AGENT IS THOUGHT TO HAVE BEEN INHALED. CONTINUOUS CLOSE OBSERVATION DURING FIRST 24 HR IS NECESSARY.)。
参见<急性刺激性气体中毒性肺水肿的治疗>。
参考文献
[1]Admiraal J; fatal inhalation of methylfluorosulfonate; Lancet 2(oct 16) 854 (1976)
[2]Hitem et al; Acute toxicity of methyl fluorosulfonate (magic methyl); Am Ind Hyg Assoc J 40(7) 600 (1979)
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